InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dlx3

Summary

InnateDB Gene

IDBG-209511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlx3

Gene Name

distal-less homeobox 3

Synonyms

AV237891; Dlx-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001510

Encoded Proteins

IDBP-209515

distal-less homeobox 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064195:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95120119-95125296

Strand

Forward strand

Band

Transcripts

ENSMUST00000092768

ENSMUSP00000090443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001568	blood vessel development
GO:0001890	placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071895	odontoblast differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000064195

View Gene Order

ENSBTAG00000017409

Not yet available

Cross-References

SwissProt

Q64205

TrEMBL

Q78ZZ8 Q9QWH3

UniProt Splice Variant

Entrez Gene

13393

UniGene

Mm.416445 Mm.5194

RefSeq

NM_010055

OMIM

CCDS

CCDS25272

HPRD

IMGT

MGI ID

MGI:94903

MGI Symbol

Dlx3

EMBL

AF452637 BC058852 CH466556 S81932 U79738

GenPept

AAB33879 AAB38415 AAH58852 AAL99502 EDL15967

RNA Seq Atlas

13393