Version 5.4
Bos taurus Gene: DLX3
Summary
InnateDB Gene IDBG-638751.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX3
Gene Name homeobox protein DLX-3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017409
Encoded Proteins
IDBP-690843
distal-less homeobox 3
IDBP-690849
distal-less homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064195:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:37294970-37300144
Strand Forward strand
Band
Transcripts
ENSBTAT00000023142 ENSBTAP00000023142
ENSBTAT00000007545 ENSBTAP00000007545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001568 blood vessel development
GO:0001890 placenta development
GO:0006355 regulation of transcription, DNA-templated
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071895 odontoblast differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000064195
View Gene Order
ENSMUSG00000001510
View Gene Order
Cross-References
SwissProt
TrEMBL A2VDN3
UniProt Splice Variant
Entrez Gene 784366
UniGene Bt.23480
RefSeq NM_001081622
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133325 DAAA02049043
GenPept AAI33326
RNA Seq Atlas 784366

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca