Version 5.4
Mus musculus Gene: Angpt4
Summary
InnateDB Gene IDBG-209584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Angpt4
Gene Name angiopoietin 4
Synonyms Agpt4; Ang3
Species Mus musculus
Ensembl Gene ENSMUSG00000027460
Encoded Proteins
IDBP-209586
angiopoietin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101280:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151911210-151945337
Strand Forward strand
Band G3
Transcripts
ENSMUST00000028955 ENSMUSP00000028955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005172 vascular endothelial growth factor receptor binding
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007492 endoderm development
GO:0010595 positive regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048014 Tie signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101280
View Gene Order
ENSBTAG00000021811
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9WVH6
TrEMBL Q3V0P7
UniProt Splice Variant
Entrez Gene 11602
UniGene Mm.189536
RefSeq NM_009641
OMIM
CCDS CCDS16874
HPRD
IMGT
MGI ID MGI:1336887
MGI Symbol Angpt4
EMBL AF113707 AK132988 BC129966 CH466551
GenPept AAD21586 AAI29967 BAE21457 EDL05940
RNA Seq Atlas 11602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca