Version 5.4
| Mus musculus Gene: Srxn1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-209605.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Srxn1 | ||||||||
| Gene Name | sulfiredoxin 1 homolog (S. cerevisiae) | ||||||||
| Synonyms | 1700127B04Rik; AI854065; AW488194; Npn3; Srx; Srx1; TX01 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000032802 | ||||||||
| Encoded Proteins |
sulfiredoxin 1 homolog (S. cerevisiae)
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation | |||||||||
| Summary |
Srxn1 is transcriptionally regulated by Nfe2l2 in immunostimulated primary macrophages that produce both reactive oxygen species and nitric oxide. The nitric oxide/Nfe2l2/Srxn1 pathway participates in the maintenance of redox homeostasis in cytokine-activated macrophages and other inflammatory settings.
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| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] SRXN1 is transcriptionally regulated by NFE2L2 in immunostimulated primary macrophages that produce both reactive oxygen species and nitric oxide. The nitric oxide/NFE2L2/SRXN1 pathway participates in the maintenance of redox homeostasis in cytokine-activated macrophages and other inflammatory settings. (Demonstrated in murine model)
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 2:152105516-152111376 | ||||||||
| Strand | Forward strand | ||||||||
| Band | G3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Mm.218639 | ||||||||
| RefSeq | NM_029688 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS16877 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | |||||||||
| MGI Symbol | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||