Version 5.4
Bos taurus Gene: SRXN1
Summary
InnateDB Gene IDBG-641453.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRXN1
Gene Name sulfiredoxin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010913
Encoded Proteins
IDBP-693816
sulfiredoxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21466852
[Homo sapiens] SRXN1 is transcriptionally regulated by NFE2L2 in immunostimulated primary macrophages that produce both reactive oxygen species and nitric oxide. The nitric oxide/NFE2L2/SRXN1 pathway participates in the maintenance of redox homeostasis in cytokine-activated macrophages and other inflammatory settings. (Demonstrated in murine model)
PMID 21466852
[Mus musculus] Srxn1 is transcriptionally regulated by Nfe2l2 in immunostimulated primary macrophages that produce both reactive oxygen species and nitric oxide. The nitric oxide/Nfe2l2/Srxn1 pathway participates in the maintenance of redox homeostasis in cytokine-activated macrophages and other inflammatory settings.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Gene Information
Type Protein coding
Genomic Location Chromosome 13:60944183-60949364
Strand Forward strand
Band
Transcripts
ENSBTAT00000014499 ENSBTAP00000014499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0032542 sulfiredoxin activity
Biological Process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000032802
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.13906
RefSeq NM_001205988
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca