Mus musculus Gene: Rbck1
Summary
InnateDB Gene IDBG-209659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbck1
Gene Name RanBP-type and C3HC4-type zinc finger containing 1
Synonyms AL033326; HOIL-1; HOIL-1L; Ubce7ip3; UIP28
Species Mus musculus
Ensembl Gene ENSMUSG00000027466
Encoded Proteins
RanBP-type and C3HC4-type zinc finger containing 1
RanBP-type and C3HC4-type zinc finger containing 1
RanBP-type and C3HC4-type zinc finger containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] RBCK1 (LUBAC) complexes with RNF31 and is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of IKBKG.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125826:
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152316334-152332653
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000028964 ENSMUSP00000028964
ENSMUST00000109847 ENSMUSP00000105473
ENSMUST00000130165
ENSMUST00000145889
ENSMUST00000144865 ENSMUSP00000118592
ENSMUST00000128645
ENSMUST00000131889
ENSMUST00000129590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060546 negative regulation of necroptotic process
GO:0097039 protein linear polyubiquitination
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0071797 LUBAC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.182145 Mm.472312
RefSeq NM_001083921 NM_019705 XM_006499445 XM_006499446
OMIM
CCDS CCDS38273
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas