InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: C20ORF18

Summary

InnateDB Gene

IDBG-641465.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C20ORF18

Gene Name

ranBP-type and C3HC4-type zinc finger-containing protein 1

Synonyms

C20ORF18

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017002

Encoded Proteins

IDBP-693835

ranBP-type and C3HC4-type zinc finger-containing protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19136968

[Homo sapiens] RBCK1 (LUBAC) complexes with RNF31 and is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of IKBKG.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125826:
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:61147247-61164402

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022612

ENSBTAP00000022612

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043130	ubiquitin binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060546	negative regulation of necroptotic process
GO:0097039	protein linear polyubiquitination
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway