Version 5.4
Mus musculus Gene: Mapk3
Summary
InnateDB Gene IDBG-209781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk3
Gene Name mitogen-activated protein kinase 3
Synonyms Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k; p44; p44erk1; p44mapk; Prkm3
Species Mus musculus
Ensembl Gene ENSMUSG00000063065
Encoded Proteins
IDBP-131638
mitogen-activated protein kinase 3
IDBP-209783
mitogen-activated protein kinase 3
IDBP-268925
mitogen-activated protein kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25538234
Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
PMID 25757564
Prostaglandin E2 transactivates Csf1r and synergizes with its signalling at Mapk1/Mapk3 level in promoting macrophage migration.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126759601-126765819
Strand Forward strand
Band F3
Transcripts
ENSMUST00000091328 ENSMUSP00000088880
ENSMUST00000057669 ENSMUSP00000051619
ENSMUST00000050201 ENSMUSP00000101969
ENSMUST00000145965
ENSMUST00000135649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019902 phosphatase binding
Biological Process
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0009887 organ morphogenesis
GO:0016310 phosphorylation
GO:0019233 sensory perception of pain
GO:0030509 BMP signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032872 regulation of stress-activated MAPK cascade
GO:0033129 positive regulation of histone phosphorylation
GO:0035066 positive regulation of histone acetylation
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051216 cartilage development
GO:0051493 regulation of cytoskeleton organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070849 response to epidermal growth factor
GO:0071260 cellular response to mechanical stimulus
GO:0072584 caveolin-mediated endocytosis
GO:0090170 regulation of Golgi inheritance
GO:2000641 regulation of early endosome to late endosome transport
GO:2000657 negative regulation of apolipoprotein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0015630 microtubule cytoskeleton
GO:0031143 pseudopodium
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_252337
SHC-related events pathway
REACT_242240
RAF/MAP kinase cascade pathway
REACT_204811
Activation of the AP-1 family of transcription factors pathway
REACT_224553
Hemostasis pathway
REACT_210065
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_210064
ERKs are inactivated pathway
REACT_254215
Signaling by GPCR pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_227951
Signaling by VEGF pathway
REACT_215063
ERK/MAPK targets pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_256157
RNA Polymerase I Promoter Opening pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_188971
Oncogene Induced Senescence pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_244029
Signal attenuation pathway
REACT_188804
Cell Cycle pathway
REACT_198535
Antiviral mechanism by IFN-stimulated genes pathway
REACT_198533
ISG15 antiviral mechanism pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_241408
M Phase pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_239466
SHC-mediated signalling pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_257981
ERK activation pathway
REACT_247448
ERK1 activation pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_188820
Cellular Senescence pathway
REACT_239722
Signalling to RAS pathway
REACT_198647
Advanced glycosylation endproduct receptor signaling pathway
REACT_260286
SHC1 events in EGFR signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_262560
Frs2-mediated activation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_257344
Golgi Cisternae Pericentriolar Stack Reorganization pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_198666
Interferon Signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_231290
Signalling to ERKs pathway
REACT_261687
Signaling by Interleukins pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_215461
Signal transduction by L1 pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_233572
Gene Expression pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_188576
Developmental Biology pathway
REACT_241824
SOS-mediated signalling pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_234035
ARMS-mediated activation pathway
REACT_250557
Mitotic Prophase pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_188529
Signaling by Leptin pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_222185
Regulation of HSF1-mediated heat shock response pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_242456
Signaling by FGFR pathway
REACT_245103
GRB2 events in EGFR signaling pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_188220
SHC-related events triggered by IGF1R pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_222431
Nuclear Events (kinase and transcription factor activation) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu04360
Axon guidance pathway
mmu05219
Bladder cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04930
Type II diabetes mellitus pathway
mmu04370
VEGF signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu05010
Alzheimer's disease pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04540
Gap junction pathway
mmu05210
Colorectal cancer pathway
mmu05216
Thyroid cancer pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05218
Melanoma pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04912
GnRH signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04520
Adherens junction pathway
mmu04150
mTOR signaling pathway pathway
mmu05215
Prostate cancer pathway
mmu04730
Long-term depression pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05212
Pancreatic cancer pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05020
Prion diseases pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04320
Dorso-ventral axis formation pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
FGF8 signaling (Mouse) pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011952
OMIM
CCDS CCDS21841
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca