InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapk3

Summary

InnateDB Protein

IDBP-268925.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Mapk3

Protein Name

mitogen-activated protein kinase 3

Synonyms

Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k; p44; p44erk1; p44mapk; Prkm3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101969

InnateDB Gene

IDBG-209781 (Mapk3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007165	signal transduction
GO:0009887	organ morphogenesis
GO:0016310	phosphorylation
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0043330	response to exogenous dsRNA
GO:0051216	cartilage development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1346859

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
IPR008350 Mitogen-activated protein (MAP) kinase, ERK3/4
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109
PR01770
PR01771

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z3G6

UniProt Splice Variant

Entrez Gene

26417

UniGene

RefSeq

MGI ID

MGI Symbol

Mapk3

OMIM

CCDS

HPRD

IMGT

EMBL

AC124505

GenPept