Version 5.4
Mus musculus Gene: Hoxb6
Summary
InnateDB Gene IDBG-209886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxb6
Gene Name homeobox B6
Synonyms Hox-2.2
Species Mus musculus
Ensembl Gene ENSMUSG00000000690
Encoded Proteins
IDBP-209888
homeobox B6
IDBP-621934
homeobox B6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108511:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:96292476-96301569
Strand Forward strand
Band D
Transcripts
ENSMUST00000000704 ENSMUSP00000000704
ENSMUST00000173432 ENSMUSP00000133281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0034101 erythrocyte homeostasis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000108511
View Gene Order
Cross-References
SwissProt P09023
TrEMBL
UniProt Splice Variant
Entrez Gene 15414
UniGene
RefSeq NM_008269
OMIM
CCDS CCDS25295
HPRD
IMGT
MGI ID MGI:96187
MGI Symbol Hoxb6
EMBL BC016893 J03782 M18166 M18401 X56459
GenPept AAA37843 AAA37844 AAC27130 AAH16893 CAA39834
RNA Seq Atlas 15414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca