InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF4H

Summary

InnateDB Gene

IDBG-21006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4H

Gene Name

eukaryotic translation initiation factor 4H

Synonyms

eIF-4H; WBSCR1; WSCR1

Species

Homo sapiens

Ensembl Gene

ENSG00000106682

Encoded Proteins

IDBP-21008

eukaryotic translation initiation factor 4H

IDBP-21010

eukaryotic translation initiation factor 4H

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:74174245-74197101

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000353999	ENSP00000265754
ENST00000265753	ENSP00000265753
ENST00000489484
ENST00000479338
ENST00000495187

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0016032	viral process
GO:0019953	sexual reproduction
GO:0044267	cellular protein metabolic process
GO:0048589	developmental growth