Version 5.4
Mus musculus Gene: Eif4h
Summary
InnateDB Gene IDBG-203011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4h
Gene Name eukaryotic translation initiation factor 4H
Synonyms AU018978; D5Ertd355e; E430026L18Rik; Ef4h; mKIAA0038; Wbscr1; Wscr1
Species Mus musculus
Ensembl Gene ENSMUSG00000040731
Encoded Proteins
IDBP-203013
eukaryotic translation initiation factor 4H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106682:
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134619880-134639348
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000036125 ENSMUSP00000048833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0019953 sexual reproduction
GO:0048589 developmental growth
Cellular Component
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106682
View Gene Order
ENSBTAG00000047249
Not yet available
Pathways
NETPATH
REACTOME
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9WUK2
TrEMBL Q3TG58 Q564E5 Q9ET00
UniProt Splice Variant
Entrez Gene 22384
UniGene Mm.428932
RefSeq NM_033561
OMIM
CCDS CCDS19723
HPRD
IMGT
MGI ID MGI:1341822
MGI Symbol Eif4h
EMBL AF139987 AF289664 AF289665 AK045004 AK088818 AK135390 AK136999 AK149841 AK150088 AK166567 AK168872 AK169312 AK169353 AK169407 BC014796 CH466529
GenPept AAD34859 AAD34860 AAF99330 AAF99335 AAH14796 BAC32180 BAC40593 BAE22517 BAE23201 BAE29116 BAE29297 BAE38858 BAE40690 BAE41067 BAE41102 BAE41153 EDL19418 EDL19419
RNA Seq Atlas 22384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca