Version 5.4
Mus musculus Gene: Sephs2
Summary
InnateDB Gene IDBG-210124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sephs2
Gene Name selenophosphate synthetase 2
Synonyms Sps2; Ysg3
Species Mus musculus
Ensembl Gene ENSMUSG00000049091
Encoded Proteins
IDBP-210126
selenophosphate synthetase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine (Sec) that is co-translationally incorporated into selenoproteins at in-frame UGA codons, which normally signal translation termination. This protein itself contains a Sec residue in its predicted active site. The 3\' UTR of this gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:127272561-127273919
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000082428 ENSMUSP00000081009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004756 selenide, water dikinase activity
GO:0005524 ATP binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0016260 selenocysteine biosynthetic process
GO:0016310 phosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179918
View Gene Order
ENSBTAG00000010851
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00450
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P97364
TrEMBL
UniProt Splice Variant
Entrez Gene 20768
UniGene Mm.20294
RefSeq NM_009266
OMIM
CCDS CCDS21863
HPRD
IMGT
MGI ID MGI:108388
MGI Symbol Sephs2
EMBL AK149516 AK168722 AK168965 BC016508 BC028966 BC043334 U43285
GenPept AAC53024 AAH16508 AAH28966 AAH43334 BAE28931 BAE40564 BAE40770
RNA Seq Atlas 20768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca