Version 5.4
Mus musculus Gene: Ctf1
Summary
InnateDB Gene IDBG-210339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctf1
Gene Name cardiotrophin 1
Synonyms CT-1
Species Mus musculus
Ensembl Gene ENSMUSG00000042340
Encoded Proteins
IDBP-210341
cardiotrophin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150281:
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:127712736-127718185
Strand Forward strand
Band F3
Transcripts
ENSMUST00000047393 ENSMUSP00000049161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005146 leukemia inhibitory factor receptor binding
Biological Process
GO:0007399 nervous system development
GO:0048666 neuron development
GO:0048861 leukemia inhibitory factor signaling pathway
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150281
View Gene Order
ENSBTAG00000017697
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q60753
TrEMBL Q541U3
UniProt Splice Variant
Entrez Gene 13019
UniGene Mm.389954 Mm.397897
RefSeq NM_007795 XM_006507316 XM_006507317 XM_006507318
OMIM
CCDS CCDS21875
HPRD
IMGT
MGI ID MGI:105115
MGI Symbol Ctf1
EMBL AY007567 BC024381 CH466531 U18366
GenPept AAC52173 AAG21821 AAH24381 EDL17575
RNA Seq Atlas 13019

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca