InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctf1

Summary

InnateDB Protein

IDBP-210341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctf1

Protein Name

cardiotrophin 1

Synonyms

CT-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049161

InnateDB Gene

IDBG-210339 (Ctf1)

Protein Structure

UniProt Annotation

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding

Biological Process

GO:0007399	nervous system development
GO:0048666	neuron development
GO:0048861	leukemia inhibitory factor signaling pathway

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:105115

InterPro

IPR009079 Four-helical cytokine-like, core

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60753

PhosphoSite

PhosphoSite-

TrEMBL

Q541U3

UniProt Splice Variant

Entrez Gene

13019

UniGene

Mm.397897

RefSeq

NP_031821

MGI ID

MGI Symbol

Ctf1

OMIM

CCDS

CCDS21875

HPRD

IMGT

EMBL

AY007567 BC024381 CH466531 U18366

GenPept

AAC52173 AAG21821 AAH24381 EDL17575