Version 5.4
Mus musculus Gene: Fbxl19
Summary
InnateDB Gene IDBG-210351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl19
Gene Name F-box and leucine-rich repeat protein 19
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030811
Encoded Proteins
IDBP-210353
F-box and leucine-rich repeat protein 19
IDBP-788918
F-box and leucine-rich repeat protein 19
IDBP-788919
F-box and leucine-rich repeat protein 19
IDBP-788922
F-box and leucine-rich repeat protein 19
IDBP-788924
F-box and leucine-rich repeat protein 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099364:
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:127745201-127769476
Strand Forward strand
Band F3
Transcripts
ENSMUST00000033081 ENSMUSP00000033081
ENSMUST00000186207 ENSMUSP00000140303
ENSMUST00000189562 ENSMUSP00000139972
ENSMUST00000186116 ENSMUSP00000140083
ENSMUST00000188580 ENSMUSP00000140021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099364
View Gene Order
ENSBTAG00000040555
Not yet available
Cross-References
SwissProt
TrEMBL Q3TSB4
UniProt Splice Variant
Entrez Gene 233902
UniGene
RefSeq XM_006507756 NM_172748 XM_006507752 XM_006507753
OMIM
CCDS CCDS21877
HPRD
IMGT
MGI ID MGI:3039600
MGI Symbol Fbxl19
EMBL AK162161
GenPept BAE36761
RNA Seq Atlas 233902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca