Version 5.4
Mus musculus Gene: Cbfa2t2
Summary
InnateDB Gene IDBG-210376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbfa2t2
Gene Name core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
Synonyms A430091M07; C330013D05Rik; Cbfa2t2h; MTGR1
Species Mus musculus
Ensembl Gene ENSMUSG00000038533
Encoded Proteins
IDBP-210378
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
IDBP-210380
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
IDBP-261780
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
IDBP-261782
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
IDBP-537986
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
IDBP-537036
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078699:
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5\'-region of the RUNX1 (AML1) gene fused to the 3\'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:154436481-154539356
Strand Forward strand
Band H1
Transcripts
ENSMUST00000099178 ENSMUSP00000096782
ENSMUST00000045270 ENSMUSP00000043087
ENSMUST00000109725 ENSMUSP00000105347
ENSMUST00000109724 ENSMUSP00000105346
ENSMUST00000155202 ENSMUSP00000116220
ENSMUST00000137526 ENSMUSP00000118371
ENSMUST00000135647
ENSMUST00000154487
ENSMUST00000139506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0030855 epithelial cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078699
View Gene Order
ENSBTAG00000010131
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 12396
UniGene Mm.29914 Mm.414642 Mm.471397
RefSeq NM_001285446 NM_009823 NM_172860 XM_006498640 XM_006498641
OMIM
CCDS CCDS16932 CCDS50764
HPRD
IMGT
MGI ID MGI:1333833
MGI Symbol Cbfa2t2
EMBL
GenPept
RNA Seq Atlas 12396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca