InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbfa2t2

Summary

InnateDB Protein

IDBP-210380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbfa2t2

Protein Name

core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)

Synonyms

A430091M07; C330013D05Rik; Cbfa2t2h; MTGR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043087

InnateDB Gene

IDBG-210376 (Cbfa2t2)

Protein Structure

UniProt Annotation

Function

May be a transcriptional corepressor. {ECO:0000269PubMed:16227606}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00440}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0030855	epithelial cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1333833

InterPro

IPR002893 Zinc finger, MYND-type
IPR003894 TAFH/NHR1
IPR013289 Eight-Twenty-One
IPR013291 Myeloid transforming gene-related protein-1 (MTGR1)
IPR014896 NHR2-like

PFAM

PF01753
PF07531
PF08788

PRINTS

PR01875
PR01877

PIRSF

SMART

SM00549

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt