Version 5.4
Mus musculus Gene: Necab3
Summary
InnateDB Gene IDBG-210399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Necab3
Gene Name N-terminal EF-hand calcium binding protein 3
Synonyms 2900010M17Rik; AI853434; Apba2bp; Nip1; XB51
Species Mus musculus
Ensembl Gene ENSMUSG00000027489
Encoded Proteins
IDBP-210401
N-terminal EF-hand calcium binding protein 3
IDBP-261794
N-terminal EF-hand calcium binding protein 3
IDBP-536912
N-terminal EF-hand calcium binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125967:
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:154544399-154558890
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000000895 ENSMUSP00000000895
ENSMUST00000109716 ENSMUSP00000105338
ENSMUST00000130824
ENSMUST00000125793 ENSMUSP00000117090
ENSMUST00000124382
ENSMUST00000135530
ENSMUST00000149725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0019538 protein metabolic process
GO:0042984 regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125967
View Gene Order
ENSBTAG00000003946
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.143748
RefSeq NM_021546
OMIM
CCDS CCDS50766
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca