Version 5.4
Mus musculus Protein: Necab3
Summary
InnateDB Protein IDBP-210401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Necab3
Protein Name N-terminal EF-hand calcium binding protein 3
Synonyms 2900010M17Rik; AI853434; Apba2bp; Nip1; XB51;
Species Mus musculus
Ensembl Protein ENSMUSP00000000895
InnateDB Gene IDBG-210399 (Necab3)
Protein Structure
UniProt Annotation
Function Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. {ECO:0000250}.
Subcellular Localization Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in the brain. {ECO:0000269PubMed:14697346}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0019538 protein metabolic process
GO:0042984 regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1861721
InterPro IPR002048 EF-hand domain
IPR007138 Antibiotic biosynthesis monooxygenase
IPR011008 Dimeric alpha-beta barrel
PFAM PF00036
PF13202
PF13405
PF03992
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D6J4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56846
UniGene Mm.143748
RefSeq NP_067521
MGI ID
MGI Symbol Necab3
OMIM
CCDS CCDS50766
HPRD
IMGT
EMBL AB039948 AK013520 AK044296 AK158225 AL772292 BC126874 BC126875 CH466551
GenPept AAI26875 AAI26876 BAB16414 BAB28895 BAC31859 BAE34411 CAM13562 CAM13563 EDL06077 EDL06081

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca