Version 5.4
Mus musculus Gene: Pigu
Summary
InnateDB Gene IDBG-210539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigu
Gene Name phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038383
Encoded Proteins
IDBP-210543
phosphatidylinositol glycan anchor biosynthesis, class U
IDBP-622617
phosphatidylinositol glycan anchor biosynthesis, class U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101464:
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:155278243-155357430
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000077626 ENSMUSP00000076816
ENSMUST00000139854
ENSMUST00000125334
ENSMUST00000124419
ENSMUST00000165234 ENSMUSP00000126236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0034235 GPI anchor binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0046425 regulation of JAK-STAT cascade
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101464
View Gene Order
ENSBTAG00000011620
Not yet available
Pathways
NETPATH
REACTOME
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_236590
Attachment of GPI anchor to uPAR pathway
KEGG
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8K358
TrEMBL
UniProt Splice Variant
Entrez Gene 228812
UniGene Mm.5434
RefSeq NM_001004721
OMIM
CCDS CCDS16946
HPRD
IMGT
MGI ID MGI:3039607
MGI Symbol Pigu
EMBL AL845325 AL929588 BC028278
GenPept AAH28278
RNA Seq Atlas 228812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca