InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Neurod2

Summary

InnateDB Gene

IDBG-210544.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neurod2

Gene Name

neurogenic differentiation 2

Synonyms

bHLHa1; Ndrf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038255

Encoded Proteins

IDBP-210546

neurogenic differentiation 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171532:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98325415-98329648

Strand

Reverse strand

Band

Transcripts

ENSMUST00000041685

ENSMUSP00000041373

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001662	behavioral fear response
GO:0006351	transcription, DNA-templated
GO:0008306	associative learning
GO:0016567	protein ubiquitination
GO:0021695	cerebellar cortex development
GO:0031915	positive regulation of synaptic plasticity
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071257	cellular response to electrical stimulus
GO:0071277	cellular response to calcium ion
GO:0090129	positive regulation of synapse maturation
GO:2000297	negative regulation of synapse maturation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171532

View Gene Order

ENSBTAG00000004119

Not yet available

Cross-References

SwissProt

Q62414

TrEMBL

Q3TYB2

UniProt Splice Variant

Entrez Gene

18013

UniGene

Mm.4814

RefSeq

NM_010895

OMIM

CCDS

CCDS25343

HPRD

IMGT

MGI ID

MGI:107755

MGI Symbol

Neurod2

EMBL

AB027126 AK158767 BC058965 CH466556 D83507 U58471

GenPept

AAC26057 AAH58965 BAA11931 BAA96490 BAE34651 EDL16125

RNA Seq Atlas

18013