InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Neurod2

Summary

InnateDB Protein

IDBP-210546.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neurod2

Protein Name

neurogenic differentiation 2

Synonyms

bHLHa1; Ndrf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041373

InnateDB Gene

IDBG-210544 (Neurod2)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter. {ECO:0000269PubMed:10648228, ECO:0000269PubMed:14697366, ECO:0000269PubMed:16203979, ECO:0000269PubMed:16504944, ECO:0000269PubMed:16730830, ECO:0000269PubMed:18214987, ECO:0000269PubMed:19900895, ECO:0000269PubMed:20346398}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:10648228, ECO:0000269PubMed:16730830}.

Disease Associations

Tissue Specificity

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level). Expressed in layers V and VI of the neocortex at postnatal day 1. Expressed in all layers of the neocortex at postnatal day 4. Strongly expressed in layer IV of the neocortex, particularly in the barrel cortex at postnatal day 7. Expressed in the CA1, CA2 and CA3 and dentate gyrus of the hippocampus and many nuclei such as the habenular thalamic nuclei, paraventricular hypothalamic nuclei, amygdala nuclei, and pyramidal nucleus. Expressed in granule cells, molecular layer neurons, and deep cerebella nuclei of the cerebellum. Expressed in brainstem neurons in the external cuneate nucleus and central gray. {ECO:0000269PubMed:14697366, ECO:0000269PubMed:16504944, ECO:0000269PubMed:20346398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001662	behavioral fear response
GO:0006351	transcription, DNA-templated
GO:0008306	associative learning
GO:0016567	protein ubiquitination
GO:0021695	cerebellar cortex development
GO:0031915	positive regulation of synaptic plasticity
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071257	cellular response to electrical stimulus
GO:0071277	cellular response to calcium ion
GO:0090129	positive regulation of synapse maturation
GO:2000297	negative regulation of synapse maturation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:107755

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function

PFAM

PF00010
PF12533

PRINTS

PIRSF

PIRSF015618

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt