InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgax

Summary

InnateDB Gene

IDBG-210550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgax

Gene Name

integrin alpha X

Synonyms

AI449405; Cd11c; Cr4; N418

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030789

Encoded Proteins

IDBP-210552

integrin alpha X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21775452

Itgax is the main marker for identification of dendritic cells (DCs). Itgax expression negatively orchestrates both adaptive and innate immunity against herpes simplex virus type 1 (HSV-1) ocular infection via higher activities of type 1 interferon and CD8(+) T cell responses.

PMID 22844116

Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

InnateDB Annotation from Orthologs

Summary

PMID 21775452

[Homo sapiens] ITAGX is the main marker for identification of dendritic cells (DCs). ITGAX expression negatively orchestrates both adaptive and innate immunity against herpes simplex virus type 1 (HSV-1) ocular infection via higher activities of type 1 interferon and CD8(+) T cell responses. (Demonstrated in murine model)

PMID 22844116

[Homo sapiens] ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140678:
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008]
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:128129547-128150656

Strand

Forward strand

Band

Transcripts

ENSMUST00000033053

ENSMUSP00000033053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.