Version 5.4
Homo sapiens Gene: ITGAX
Summary
InnateDB Gene IDBG-28212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGAX
Gene Name integrin, alpha X (complement component 3 receptor 4 subunit)
Synonyms CD11C; SLEB6
Species Homo sapiens
Ensembl Gene ENSG00000140678
Encoded Proteins
IDBP-28214
integrin, alpha X (complement component 3 receptor 4 subunit)
IDBP-751170
IDBP-808032
integrin, alpha X (complement component 3 receptor 4 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21775452
ITAGX is the main marker for identification of dendritic cells (DCs). ITGAX expression negatively orchestrates both adaptive and innate immunity against herpes simplex virus type 1 (HSV-1) ocular infection via higher activities of type 1 interferon and CD8(+) T cell responses. (Demonstrated in murine model)
PMID 22844116
ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
InnateDB Annotation from Orthologs
Summary
PMID 21775452
[Mus musculus] Itgax is the main marker for identification of dendritic cells (DCs). Itgax expression negatively orchestrates both adaptive and innate immunity against herpes simplex virus type 1 (HSV-1) ocular infection via higher activities of type 1 interferon and CD8(+) T cell responses.
PMID 22844116
[Mus musculus] Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
Entrez Gene
Summary This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008]
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31355134-31382997
Strand Forward strand
Band p11.2
Transcripts
ENST00000268296 ENSP00000268296
ENST00000562522 ENSP00000454623
ENST00000567409
ENST00000562138
ENST00000562918 ENSP00000483860
ENST00000571644
ENST00000564308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 6 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0009887 organ morphogenesis
GO:0030198 extracellular matrix organization
GO:0045087 innate immune response (InnateDB)
GO:0050900 leukocyte migration
GO:0051607 defense response to virus
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030789
View Gene Order
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin_cs_pathway
Integrin family cell surface interactions
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.248472
RefSeq NM_000887 NM_001286375
HUGO
OMIM
CCDS CCDS10711 CCDS67014
HPRD 01051
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca