Version 5.4
Mus musculus Gene: Ncoa6
Summary
InnateDB Gene IDBG-210562.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncoa6
Gene Name nuclear receptor coactivator 6
Synonyms AIB3; ASC-2; ASC2; mKIAA0181; Ncoa7; NRC; PRIP; RAP250
Species Mus musculus
Ensembl Gene ENSMUSG00000038369
Encoded Proteins
IDBP-210564
nuclear receptor coactivator 6
IDBP-261900
nuclear receptor coactivator 6
IDBP-261902
nuclear receptor coactivator 6
IDBP-536578
nuclear receptor coactivator 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198646:
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:155390656-155473894
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000043126 ENSMUSP00000045386
ENSMUST00000109670 ENSMUSP00000105295
ENSMUST00000109669 ENSMUSP00000105294
ENSMUST00000146942
ENSMUST00000143909
ENSMUST00000123293 ENSMUSP00000118113
ENSMUST00000141928
ENSMUST00000134508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 83 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0007507 heart development
GO:0030099 myeloid cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0035097 histone methyltransferase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198646
View Gene Order
ENSBTAG00000007930
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.27592 Mm.489368
RefSeq NM_001242558 NM_019825 XM_006499927 XM_006499928
OMIM
CCDS CCDS38295
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca