InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCOA6

Summary

InnateDB Gene

IDBG-68724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA6

Gene Name

nuclear receptor coactivator 6

Synonyms

AIB3; ASC2; NRC; PRIP; RAP250; TRBP

Species

Homo sapiens

Ensembl Gene

ENSG00000198646

Encoded Proteins

IDBP-68726

nuclear receptor coactivator 6

IDBP-68728

nuclear receptor coactivator 6

IDBP-813325

nuclear receptor coactivator 6

IDBP-813326

nuclear receptor coactivator 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:34696918-34825649

Strand

Reverse strand

Band

q11.22

Transcripts

ENST00000359003	ENSP00000351894
ENST00000374796	ENSP00000363929
ENST00000434040
ENST00000471897
ENST00000593786
ENST00000612493	ENSP00000481177
ENST00000616167	ENSP00000481935

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	118 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006352	DNA-templated transcription, initiation
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0007420	brain development
GO:0007507	heart development
GO:0009725	response to hormone
GO:0030099	myeloid cell differentiation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042921	glucocorticoid receptor signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0035097	histone methyltransferase complex
GO:0043231	intracellular membrane-bounded organelle