InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tcap

Summary

InnateDB Gene

IDBG-210565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcap

Gene Name

titin-cap

Synonyms

AI503981; AJ223855

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007877

Encoded Proteins

IDBP-210567

titin-cap

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173991:
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98383811-98384953

Strand

Forward strand

Band

Transcripts

ENSMUST00000008021

ENSMUSP00000008021

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0030674	protein binding, bridging
GO:0031432	titin binding
GO:0044325	ion channel binding
GO:0051373	FATZ binding
GO:0070080	titin Z domain binding

Biological Process

GO:0001756	somitogenesis
GO:0003009	skeletal muscle contraction
GO:0003300	cardiac muscle hypertrophy
GO:0007512	adult heart development
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030240	skeletal muscle thin filament assembly
GO:0030241	skeletal muscle myosin thick filament assembly
GO:0030916	otic vesicle formation
GO:0035995	detection of muscle stretch
GO:0045214	sarcomere organization
GO:0048739	cardiac muscle fiber development
GO:0048769	sarcomerogenesis
GO:0055003	cardiac myofibril assembly
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0030018	Z disc
GO:0031674	I band

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000173991

View Gene Order

ENSBTAG00000011730

Not yet available

Pathways

NETPATH

REACTOME

REACT_232053

Striated Muscle Contraction pathway

REACT_262759

Muscle contraction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

REACT_213099

Muscle contraction pathway

REACT_223821

Striated Muscle Contraction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O70548

TrEMBL

Q545G3

UniProt Splice Variant

Entrez Gene

21393

UniGene

RefSeq

NM_011540

OMIM

CCDS

CCDS25346

HPRD

IMGT

MGI ID

MGI:1330233

MGI Symbol

Tcap

EMBL

AJ223854 AK010167 BC027631 CH466556 Y15845

GenPept

AAH27631 BAB26743 CAA11585 CAB38077 EDL16136

RNA Seq Atlas

21393