InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcap

Summary

InnateDB Protein

IDBP-210567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcap

Protein Name

titin-cap

Synonyms

AI503981; AJ223855;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008021

InnateDB Gene

IDBG-210565 (Tcap)

Protein Structure

UniProt Annotation

Function

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0030674	protein binding, bridging
GO:0031432	titin binding
GO:0044325	ion channel binding
GO:0051373	FATZ binding
GO:0070080	titin Z domain binding

Biological Process

GO:0001756	somitogenesis
GO:0003009	skeletal muscle contraction
GO:0003300	cardiac muscle hypertrophy
GO:0007512	adult heart development
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030240	skeletal muscle thin filament assembly
GO:0030241	skeletal muscle myosin thick filament assembly
GO:0030916	otic vesicle formation
GO:0035995	detection of muscle stretch
GO:0045214	sarcomere organization
GO:0048739	cardiac muscle fiber development
GO:0048769	sarcomerogenesis
GO:0055003	cardiac myofibril assembly
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction