InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tial1

Summary

InnateDB Gene

IDBG-210657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tial1

Gene Name

Tia1 cytotoxic granule-associated RNA binding protein-like 1

Synonyms

5330433G13Rik; AL033329; mTIAR; TIAR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030846

Encoded Proteins

IDBP-210659

Tia1 cytotoxic granule-associated RNA binding protein-like 1

IDBP-269216

Tia1 cytotoxic granule-associated RNA binding protein-like 1

IDBP-269218

Tia1 cytotoxic granule-associated RNA binding protein-like 1

IDBP-532037

Tia1 cytotoxic granule-associated RNA binding protein-like 1

IDBP-623115

Tia1 cytotoxic granule-associated RNA binding protein-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151923:
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:128439777-128461717

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033135	ENSMUSP00000033135
ENSMUST00000106228	ENSMUSP00000101835
ENSMUST00000106226	ENSMUSP00000101833
ENSMUST00000133444
ENSMUST00000141079
ENSMUST00000123666	ENSMUSP00000116921
ENSMUST00000141126
ENSMUST00000133089
ENSMUST00000152328
ENSMUST00000136782
ENSMUST00000165023	ENSMUSP00000126458

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0007281	germ cell development
GO:0008284	positive regulation of cell proliferation
GO:0017145	stem cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151923

View Gene Order

ENSBTAG00000004080

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q6NVC2 Q8C573 Q921W2

UniProt Splice Variant

Entrez Gene

21843

UniGene

Mm.242072 Mm.413189 Mm.470373

RefSeq

NM_009383 XM_006507574

OMIM

CCDS

CCDS21897

HPRD

IMGT

MGI ID

MGI:107913

MGI Symbol

Tial1

EMBL

AC130474 AK079363 BC010496 BC068194 CH466531

GenPept

AAH10496 AAH68194 BAC37623 EDL17647

RNA Seq Atlas

21843