InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gdf5

Summary

InnateDB Gene

IDBG-210734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf5

Gene Name

growth differentiation factor 5

Synonyms

BMP-14; bp; brp; Cdmp-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038259

Encoded Proteins

IDBP-210736

growth differentiation factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125965:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:155941023-155945367

Strand

Reverse strand

Band

Transcripts

ENSMUST00000040162

ENSMUSP00000048079

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0040007	growth
GO:0040014	regulation of multicellular organism growth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0050680	negative regulation of epithelial cell proliferation
GO:2001054	negative regulation of mesenchymal cell apoptotic process