InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.86382

Summary

InnateDB Gene

IDBG-642165.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.86382

Gene Name

growth/differentiation factor 5 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004429

Encoded Proteins

IDBP-694586

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125965:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:65340132-65343889

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005807

ENSBTAP00000005807

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0040007	growth
GO:0040014	regulation of multicellular organism growth
GO:0050680	negative regulation of epithelial cell proliferation
GO:2001054	negative regulation of mesenchymal cell apoptotic process