Version 5.4
Mus musculus Gene: Nr1d1
Summary
InnateDB Gene IDBG-210758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr1d1
Gene Name nuclear receptor subfamily 1, group D, member 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020889
Encoded Proteins
IDBP-210760
nuclear receptor subfamily 1, group D, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126368:
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98767932-98775333
Strand Reverse strand
Band D
Transcripts
ENSMUST00000064941 ENSMUSP00000069505
ENSMUST00000139220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001222 transcription corepressor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0020037 heme binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0005978 glycogen biosynthetic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007623 circadian rhythm
GO:0010498 proteasomal protein catabolic process
GO:0010871 negative regulation of receptor biosynthetic process
GO:0019216 regulation of lipid metabolic process
GO:0030154 cell differentiation
GO:0032922 circadian regulation of gene expression
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0042752 regulation of circadian rhythm
GO:0043401 steroid hormone mediated signaling pathway
GO:0044321 response to leptin
GO:0045598 regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060086 circadian temperature homeostasis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469 regulation of type B pancreatic cell proliferation
GO:0070859 positive regulation of bile acid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:2000188 regulation of cholesterol homeostasis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0030425 dendrite
GO:0043197 dendritic spine
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126368
View Gene Order
ENSBTAG00000012178
Not yet available
Pathways
NETPATH
REACTOME
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
mmu04710
Circadian rhythm pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_226022
Gene Expression pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_210423
Nuclear Receptor transcription pathway pathway
REACT_224346
REV-ERBA represses gene expression pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_215625
RORA activates circadian gene expression pathway
REACT_210271
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_227144
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.390397 Mm.481284
RefSeq NM_145434
OMIM
CCDS CCDS25363
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca