InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr7

Summary

InnateDB Gene

IDBG-210918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr7

Gene Name

chemokine (C-C motif) receptor 7

Synonyms

CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7; EBI1; Ebi1h

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037944

Encoded Proteins

IDBP-210920

chemokine (C-C motif) receptor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20176793

[Homo sapiens] CCR7 is a chemokine receptor expressed on the surfaces of T cells, B cells, and mature dendritic cells that controls cell migration in response to the cognate ligands CCL19 and CCL21. CCR7 deficiency results in a heightened pro-inflammatory environment in response to acute pulmonary P. aeruginosa infection and contributes to more efficient clearance.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126353:
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:99144196-99155077

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103134

ENSMUSP00000099423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0035757	chemokine (C-C motif) ligand 19 binding
GO:0035758	chemokine (C-C motif) ligand 21 binding
GO:0038117	C-C motif chemokine 19 receptor activity
GO:0038121	C-C motif chemokine 21 receptor activity

Biological Process

GO:0001768	establishment of T cell polarity
GO:0002408	myeloid dendritic cell chemotaxis
GO:0002518	lymphocyte chemotaxis across high endothelial venule
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002649	regulation of tolerance induction to self antigen
GO:0002885	positive regulation of hypersensitivity
GO:0002922	positive regulation of humoral immune response
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0010759	positive regulation of macrophage chemotaxis
GO:0010820	positive regulation of T cell chemotaxis
GO:0030036	actin cytoskeleton organization
GO:0032320	positive regulation of Ras GTPase activity
GO:0032496	response to lipopolysaccharide
GO:0032649	regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034695	response to prostaglandin E
GO:0038115	chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0045060	negative thymic T cell selection
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048535	lymph node development
GO:0050706	regulation of interleukin-1 beta secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050766	positive regulation of phagocytosis
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0051491	positive regulation of filopodium assembly
GO:0071345	cellular response to cytokine stimulus
GO:0071731	response to nitric oxide
GO:0072610	interleukin-12 secretion
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097022	lymphocyte migration into lymph node
GO:0097029	mature dendritic cell differentiation
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000412	positive regulation of thymocyte migration
GO:2000510	positive regulation of dendritic cell chemotaxis
GO:2000522	positive regulation of immunological synapse formation
GO:2000525	positive regulation of T cell costimulation
GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547	regulation of dendritic cell dendrite assembly

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane