Version 5.4
Mus musculus Gene: Krt14
Summary
InnateDB Gene IDBG-211284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt14
Gene Name keratin 14
Synonyms AI626930; K14; Krt-1.14; Krt1-14
Species Mus musculus
Ensembl Gene ENSMUSG00000045545
Encoded Proteins
IDBP-211286
keratin 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186847:
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:100203162-100207548
Strand Reverse strand
Band D
Transcripts
ENSMUST00000007272 ENSMUSP00000007272
ENSMUST00000137265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:1990254 keratin filament binding
Biological Process
GO:0007568 aging
GO:0010043 response to zinc ion
GO:0010212 response to ionizing radiation
GO:0030855 epithelial cell differentiation
GO:0042633 hair cycle
GO:0045110 intermediate filament bundle assembly
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186847
View Gene Order
ENSBTAG00000007583
Not yet available
Pathways
NETPATH
REACTOME
REACT_262098
Type I hemidesmosome assembly pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt Q61781
TrEMBL
UniProt Splice Variant
Entrez Gene 16664
UniGene Mm.439898
RefSeq NM_016958 XM_006532330
OMIM
CCDS CCDS25413
HPRD
IMGT
MGI ID MGI:96688
MGI Symbol Krt14
EMBL AL590873 BC003325 BC011074 M13806
GenPept AAA39392 AAH03325 AAH11074 CAM17776
RNA Seq Atlas 16664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca