Version 5.4
Mus musculus Gene: Adam12
Summary
InnateDB Gene IDBG-211287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam12
Gene Name a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms mKIAA4001; Mltna
Species Mus musculus
Ensembl Gene ENSMUSG00000054555
Encoded Proteins
IDBP-211289
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
IDBP-540128
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
IDBP-533103
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
IDBP-537327
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148848:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:133883199-134232146
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000067680 ENSMUSP00000065213
ENSMUST00000138363 ENSMUSP00000114874
ENSMUST00000134504 ENSMUSP00000123161
ENSMUST00000127524 ENSMUSP00000120094
ENSMUST00000154144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148848
View Gene Order
ENSBTAG00000012444
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_242976
Signaling by EGFR pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
syndecan_4_pathway
Syndecan-4-mediated signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.439714
RefSeq NM_007400 XM_006507208
OMIM
CCDS CCDS21938
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca