InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stat5b

Summary

InnateDB Gene

IDBG-211594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat5b

Gene Name

signal transducer and activator of transcription 5B

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020919

Encoded Proteins

IDBP-211596

signal transducer and activator of transcription 5B

IDBP-266835

signal transducer and activator of transcription 5B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 9398404

[Homo sapiens] IL-2 and IL-7 induced heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblast

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173757:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100780731-100850724

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004143	ENSMUSP00000004143
ENSMUST00000107358	ENSMUSP00000102981
ENSMUST00000126266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	18 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000255	allantoin metabolic process
GO:0001553	luteinization
GO:0001666	response to hypoxia
GO:0001779	natural killer cell differentiation
GO:0001889	liver development
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007548	sex differentiation
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0019218	regulation of steroid metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0019915	lipid storage
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0032870	cellular response to hormone stimulus
GO:0033077	T cell differentiation in thymus
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0042448	progesterone metabolic process
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046449	creatinine metabolic process
GO:0046543	development of secondary female sexual characteristics
GO:0046544	development of secondary male sexual characteristics
GO:0048541	Peyer's patch development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051272	positive regulation of cellular component movement
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0070672	response to interleukin-15
GO:0071363	cellular response to growth factor stimulus
GO:0071364	cellular response to epidermal growth factor stimulus