InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stat5b

Summary

InnateDB Protein

IDBP-266835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat5b

Protein Name

signal transducer and activator of transcription 5B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102981

InnateDB Gene

IDBG-211594 (Stat5b)

Protein Structure

UniProt Annotation

Function

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. {ECO:0000269PubMed:11773439}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Disease Associations

Tissue Specificity

In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	18 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000255	allantoin metabolic process
GO:0001553	luteinization
GO:0001666	response to hypoxia
GO:0001779	natural killer cell differentiation
GO:0001889	liver development
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007548	sex differentiation
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0019218	regulation of steroid metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0019915	lipid storage
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0032870	cellular response to hormone stimulus
GO:0033077	T cell differentiation in thymus
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0042448	progesterone metabolic process
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046449	creatinine metabolic process
GO:0046543	development of secondary female sexual characteristics
GO:0046544	development of secondary male sexual characteristics
GO:0048541	Peyer's patch development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051272	positive regulation of cellular component movement
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0070672	response to interleukin-15
GO:0071363	cellular response to growth factor stimulus
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:103035

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt