InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptrf

Summary

InnateDB Gene

IDBG-211692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptrf

Gene Name

polymerase I and transcript release factor

Synonyms

2310075E07Rik; AW546441; Cav-p60; Cavin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004044

Encoded Proteins

IDBP-211694

polymerase I and transcript release factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177469:
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100956733-100970887

Strand

Reverse strand

Band

Transcripts

ENSMUST00000060792	ENSMUSP00000058321
ENSMUST00000132934

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042134	rRNA primary transcript binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177469

View Gene Order

ENSBTAG00000039684

Not yet available

Pathways

NETPATH

REACTOME

REACT_245058

RNA Polymerase I Transcription pathway

REACT_244415

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_257165

RNA Polymerase I Transcription Termination pathway

REACT_233572

Gene Expression pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_1074

RNA Polymerase I Transcription Termination pathway

REACT_1309

RNA Polymerase I Transcription pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.21864 Mm.400517

RefSeq

NM_008986

OMIM

CCDS

CCDS25442

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas