InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: B4GALT6

Summary

InnateDB Gene

IDBG-2120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4GALT6

Gene Name

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

Synonyms

B4Gal-T6; beta4Gal-T6

Species

Homo sapiens

Ensembl Gene

ENSG00000118276

Encoded Proteins

IDBP-2122

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

IDBP-2124

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

IDBP-2126

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

IDBP-726728

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:31622247-31685836

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000306851	ENSP00000306459
ENST00000237019	ENSP00000237019
ENST00000383131	ENSP00000372613
ENST00000578114
ENST00000579372	ENSP00000463961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008378	galactosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process