Mus musculus Gene: Hras1

Summary
InnateDB Gene IDBG-212024.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Hras1
Gene Name Harvey rat sarcoma virus oncogene 1
Synonyms c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras-1; Kras2; ras
Species Mus musculus
Ensembl Gene ENSMUSG00000025499
Encoded Proteins
IDBP-212026 Harvey rat sarcoma virus oncogene 1
IDBP-212030 Harvey rat sarcoma virus oncogene 1
IDBP-626472 Harvey rat sarcoma virus oncogene 1
InnateDB Annotation from Orthologs
Summary
PMID 12867418 [Homo sapiens] HRAS participates in CpG oligodeoxynucleotide signalling through association with TLR9 and promotion of IRAK1/TRAF6 complex formation in macrophages.
PMID 11744690 [Homo sapiens] HRAS participates in the activation of MAPK1 by IL1A (IL-1) through association with IRAK1, IRAK2, TRAF6 and MAP3K7.
PMID 20501842 [Homo sapiens] HRAS promotes virus spread by suppressing viral RNA-induced IFN-beta production through negative regulation of RIG-I signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174775:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7: 141189105-141194005
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000026572  ENSMUSP00000026572
ENSMUST00000097957  ENSMUSP00000095570
ENSMUST00000128993 
ENSMUST00000124314 
ENSMUST00000124971 
ENSMUST00000134008 
ENSMUST00000168550  ENSMUSP00000132110
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein‑Protein  28
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 2
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 80 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0006917 induction of apoptosis
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0015031 protein transport
GO:0015684 ferrous iron transport
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0031575 mitotic cell cycle G1/S transition checkpoint
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0051384 response to glucocorticoid stimulus
GO:0051385 response to mineralocorticoid stimulus
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000174775 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000046644 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_76978 Interleukin receptor SHC signaling
REACT_101367 RAF activation
REACT_141113 Ras activation uopn Ca2+ infux through NMDA receptor
KEGG
mmu05221  Acute myeloid leukemia
mmu04360  Axon guidance
mmu04662  B cell receptor signaling pathway
mmu05219  Bladder cancer
mmu04062  Chemokine signaling pathway
mmu05220  Chronic myeloid leukemia
mmu04144  Endocytosis
mmu05213  Endometrial cancer
mmu04012  ErbB signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04510  Focal adhesion
mmu04540  Gap junction
mmu05214  Glioma
mmu04912  GnRH signaling pathway
mmu05160  Hepatitis C
mmu04910  Insulin signaling pathway
mmu04730  Long-term depression
mmu04720  Long-term potentiation
mmu04010  MAPK signaling pathway
mmu04916  Melanogenesis
mmu05218  Melanoma
mmu04650  Natural killer cell mediated cytotoxicity
mmu04722  Neurotrophin signaling pathway
mmu05223  Non-small cell lung cancer
mmu05200  Pathways in cancer
mmu05215  Prostate cancer
mmu04810  Regulation of actin cytoskeleton
mmu05211  Renal cell carcinoma
mmu04660  T cell receptor signaling pathway
mmu05216  Thyroid cancer
mmu04530  Tight junction
mmu04370  VEGF signaling pathway
INOH
INOH website B cell receptor signaling
INOH website CD4 T cell receptor signaling
INOH website EGF signaling pathway
INOH website FGF8 signaling (Mouse)
INOH website FGF signaling pathway
INOH website HGF signaling pathway
INOH website Insulin receptor signaling
INOH website Integrin signaling pathway
INOH website JAK STAT pathway and regulation
INOH website NGF signaling pathway
INOH website PDGF signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4 EGFR1 pathway
NetPath_15 IL3 pathway
NetPath_17 IL5 pathway
NetPath_18 IL6 pathway
NetPath_6 KitReceptor pathway
NetPath_56 Prolactin pathway
NetPath_23 TSH pathway
REACTOME
REACT_118778 Activation of RAS in B Cells
REACT_147814 DAP12 signaling
REACT_17025 Downstream signal transduction
REACT_121096 EGFR Transactivation by Gastrin
REACT_21247 FRS2-mediated cascade
REACT_12606 GRB2 events in EGFR signaling
REACT_115854 GRB2 events in ERBB2 signaling
REACT_23891 Interleukin receptor SHC signaling
REACT_962 MEK activation
REACT_18334 NCAM signaling for neurite out-growth
REACT_2077 RAF activation
REACT_614 RAF phosphorylates MEK
REACT_20546 Ras activation uopn Ca2+ infux through NMDA receptor
REACT_12579 SHC1 events in EGFR signaling
REACT_115993 SHC1 events in ERBB2 signaling
REACT_116005 SHC1 events in ERBB4 signaling
REACT_21374 SHC-mediated cascade
REACT_661 SHC-mediated signalling
REACT_524 SOS-mediated signalling
REACT_121398 Signaling by FGFR mutants
REACT_111040 Signaling by SCF-KIT
REACT_115852 Signaling by constitutively active EGFR
REACT_12033 Signalling to RAS
REACT_12621 Tie2 Signaling
REACT_12065 p38MAPK events
KEGG
hsa05221  Acute myeloid leukemia
hsa04360  Axon guidance
hsa04662  B cell receptor signaling pathway
hsa05219  Bladder cancer
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa04144  Endocytosis
hsa05213  Endometrial cancer
hsa04012  ErbB signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa05214  Glioma
hsa04912  GnRH signaling pathway
hsa05160  Hepatitis C
hsa04910  Insulin signaling pathway
hsa04730  Long-term depression
hsa04720  Long-term potentiation
hsa04010  MAPK signaling pathway
hsa04916  Melanogenesis
hsa05218  Melanoma
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa05223  Non-small cell lung cancer
hsa05200  Pathways in cancer
hsa05215  Prostate cancer
hsa04810  Regulation of actin cytoskeleton
hsa05211  Renal cell carcinoma
hsa04660  T cell receptor signaling pathway
hsa05216  Thyroid cancer
hsa04530  Tight junction
hsa04370  VEGF signaling pathway
INOH
INOH website B cell receptor signaling
INOH website CD4 T cell receptor signaling
INOH website EGF signaling pathway
INOH website FGF signaling pathway
INOH website HGF signaling pathway
INOH website IGF1 signaling pathway
INOH website Insulin receptor signaling
INOH website Integrin signaling pathway
INOH website JAK STAT pathway and regulation
INOH website NGF signaling pathway
INOH website PDGF signaling pathway
PID BIOCARTA
100236 Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
100030 Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
100227 Bcr signaling pathway [Biocarta view]
100226 Bioactive peptide induced signaling pathway [Biocarta view]
100209 Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
100150 Calcium signaling by hbx of hepatitis b virus [Biocarta view]
100215 Ccr3 signaling in eosinophils [Biocarta view]
100192 Cxcr4 signaling pathway [Biocarta view]
100181 Egf signaling pathway [Biocarta view]
100175 Epo signaling pathway [Biocarta view]
100170 Erk1/erk2 mapk signaling pathway [Biocarta view]
100165 Fc epsilon receptor i signaling in mast cells [Biocarta view]
100162 Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
100104 How progesterone initiates the oocyte maturation [Biocarta view]
100136 Igf-1 signaling pathway [Biocarta view]
100130 Il 2 signaling pathway [Biocarta view]
100128 Il 3 signaling pathway [Biocarta view]
100126 Il 6 signaling pathway [Biocarta view]
100129 Il-2 receptor beta chain in t cell activation [Biocarta view]
100054 Influence of ras and rho proteins on g1 to s transition [Biocarta view]
100154 Inhibition of cellular proliferation by gleevec [Biocarta view]
100124 Insulin signaling pathway [Biocarta view]
100123 Integrin signaling pathway [Biocarta view]
100119 Keratinocyte differentiation [Biocarta view]
100057 Links between pyk2 and map kinases [Biocarta view]
100032 Map kinase inactivation of smrt corepressor [Biocarta view]
100113 Mapkinase signaling pathway [Biocarta view]
100111 Mcalpain and friends in cell motility [Biocarta view]
100108 Melanocyte development and pigmentation pathway [Biocarta view]
100169 Mets affect on macrophage differentiation [Biocarta view]
100135 Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
100096 Nerve growth factor pathway (ngf) [Biocarta view]
100098 Nfat and hypertrophy of the heart [Biocarta view]
100085 P38 mapk signaling pathway [Biocarta view]
100077 Pdgf signaling pathway [Biocarta view]
100183 Phospholipids as signalling intermediaries [Biocarta view]
100210 Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
100047 Ras signaling pathway [Biocarta view]
100036 Regulation of splicing through sam68 [Biocarta view]
100221 Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
100147 Role of erbb2 in signal transduction and oncology [Biocarta view]
100171 Role of erk5 in neuronal survival pathway [Biocarta view]
100114 Role of mal in rho-mediated activation of srf [Biocarta view]
100230 Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
100153 Signaling pathway from g-protein families [Biocarta view]
100029 Sprouty regulation of tyrosine kinase signals [Biocarta view]
100022 T cell receptor signaling pathway [Biocarta view]
100115 The igf-1 receptor and longevity [Biocarta view]
100012 Tpo signaling pathway [Biocarta view]
100198 Transcription factor creb and its extracellular signals [Biocarta view]
100018 Trefoil factors initiate mucosal healing [Biocarta view]
100011 Trka receptor signaling pathway [Biocarta view]
100006 Vegf hypoxia and angiogenesis [Biocarta view]
PID NCI
bcr_5pathway BCR signaling pathway
cdc42_pathway CDC42 signaling events
et_egfrpathway EGFR-dependent Endothelin signaling events
ephbfwdpathway EPHB forward signaling
epopathway EPO signaling pathway
endothelinpathway Endothelins
fcer1pathway Fc-epsilon receptor I signaling in mast cells
igf1_pathway IGF1 pathway
insulin_pathway Insulin Pathway
lysophospholipid_pathway LPA receptor mediated events
ar_nongenomic_pathway Nongenotropic Androgen signaling
ajdiss_2pathway Posttranslational regulation of adherens junction stability and dissassembly
ras_pathway Regulation of Ras family activation
met_pathway Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
kitpathway Signaling events mediated by Stem cell factor receptor (c-Kit)
ret_pathway Signaling events regulated by Ret tyrosine kinase
syndecan_2_pathway Syndecan-2-mediated signaling events
a6b1_a6b4_integrin_pathway a6b1 and a6b4 Integrin signaling
Cross-References
SwissProt Q61411 
TrEMBL B2KGV5 F7BIB2 P97870 Q53WZ3 Q71SW8 Q9QWR5
UniProt Splice Variant
Entrez Gene 15461 
UniGene Mm.334313
RefSeq NM_001130444  NM_008284 
OMIM
CCDS CCDS22003  CCDS52439 
HPRD
IMGT
MGI ID MGI:96224 
MGI Symbol Hras1
EMBL AC108908 AC157091 AF268311 AJ437023 AY373386 BC061885 CH466531 CU458742 D00836 S39586 S74119 U89950 Z50013
GenPept AAB50559  AAF74295  AAH61885  AAO46052  AAP21090  AAQ81319  BAA28218  CAA90306  CAD24593  CAQ52126  EDL18008  EDL18009 
ImmGen Hras1 (murine) 
RNA Seq Atlas 15461