Version 5.4
Mus musculus Gene: Hras1
Summary
InnateDB Gene IDBG-212024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hras1
Gene Name Harvey rat sarcoma virus oncogene 1
Synonyms c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras-1; Hras1; Kras2; ras
Species Mus musculus
Ensembl Gene ENSMUSG00000025499
Encoded Proteins
IDBP-212026
Harvey rat sarcoma virus oncogene 1
IDBP-212030
Harvey rat sarcoma virus oncogene 1
IDBP-790376
Harvey rat sarcoma virus oncogene
IDBP-626472
Harvey rat sarcoma virus oncogene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12867418
[Homo sapiens] HRAS participates in CpG oligodeoxynucleotide signalling through association with TLR9 and promotion of IRAK1/TRAF6 complex formation in macrophages.
PMID 11744690
[Homo sapiens] HRAS participates in the activation of MAPK1 by IL1A (IL-1) through association with IRAK1, IRAK2, TRAF6 and MAP3K7.
PMID 20501842
[Homo sapiens] HRAS promotes virus spread by suppressing viral RNA-induced IFN-beta production through negative regulation of RIG-I signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174775:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141189105-141194005
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000026572 ENSMUSP00000026572
ENSMUST00000097957 ENSMUSP00000095570
ENSMUST00000128993
ENSMUST00000124314
ENSMUST00000124971 ENSMUSP00000138189
ENSMUST00000134008
ENSMUST00000168550 ENSMUSP00000132110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
GO:0032403 protein complex binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0015684 ferrous iron transport
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032855 positive regulation of Rac GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090303 positive regulation of wound healing
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900029 positive regulation of ruffle assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174775
View Gene Order
ENSBTAG00000046644
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_189085
Disease pathway
REACT_252337
SHC-related events pathway
REACT_242240
RAF/MAP kinase cascade pathway
REACT_224553
Hemostasis pathway
REACT_199123
Signaling by constitutively active EGFR pathway
REACT_254215
Signaling by GPCR pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_257146
RAF phosphorylates MEK pathway
REACT_227951
Signaling by VEGF pathway
REACT_198350
EGFR Transactivation by Gastrin pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_230745
Immune System pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_239466
SHC-mediated signalling pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_239722
Signalling to RAS pathway
REACT_260286
SHC1 events in EGFR signaling pathway
REACT_237640
RAF activation pathway
REACT_199122
Activation of RAS in B cells pathway
REACT_242976
Signaling by EGFR pathway
REACT_262560
Frs2-mediated activation pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_207601
p38MAPK events pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_231290
Signalling to ERKs pathway
REACT_261687
Signaling by Interleukins pathway
REACT_196455
Signaling by FGFR mutants pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_94437
SHC-mediated cascade pathway
REACT_241824
SOS-mediated signalling pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_234035
ARMS-mediated activation pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_188529
Signaling by Leptin pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_211860
Tie2 Signaling pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_242456
Signaling by FGFR pathway
REACT_245103
GRB2 events in EGFR signaling pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_247566
MEK activation pathway
REACT_188220
SHC-related events triggered by IGF1R pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04530
Tight junction pathway
mmu05213
Endometrial cancer pathway
mmu04360
Axon guidance pathway
mmu05219
Bladder cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04540
Gap junction pathway
mmu05216
Thyroid cancer pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05218
Melanoma pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04912
GnRH signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu05215
Prostate cancer pathway
mmu04730
Long-term depression pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_2077
RAF activation pathway
REACT_614
RAF phosphorylates MEK pathway
REACT_962
MEK activation pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_118778
Activation of RAS in B cells pathway
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12065
p38MAPK events pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_524
SOS-mediated signalling pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04360
Axon guidance pathway
hsa05216
Thyroid cancer pathway
hsa05213
Endometrial cancer pathway
hsa04720
Long-term potentiation pathway
hsa05219
Bladder cancer pathway
hsa04530
Tight junction pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04730
Long-term depression pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
ar_nongenomic_pathway
Nongenotropic Androgen signaling
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
lysophospholipid_pathway
LPA receptor mediated events
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
igf1_pathway
IGF1 pathway
epopathway
EPO signaling pathway
ephbfwdpathway
EPHB forward signaling
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
et_egfrpathway
EGFR-dependent Endothelin signaling events
ras_pathway
Regulation of Ras family activation
cdc42_pathway
CDC42 signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
insulin_pathway
Insulin Pathway
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt Q61411
TrEMBL B2KGV5 P97870 Q53WZ3 Q71SW8 Q9QWR5
UniProt Splice Variant
Entrez Gene 15461
UniGene Mm.334313
RefSeq NM_001130444 XM_006536160 NM_001130443 NM_008284 XM_006536157
OMIM
CCDS CCDS52439 CCDS22003
HPRD
IMGT
MGI ID MGI:96224
MGI Symbol Hras
EMBL AC108908 AC157091 AF268311 AJ437023 AY373386 BC061885 CH466531 D00836 S39586 S74119 U89950 Z50013
GenPept AAB50559 AAF74295 AAH61885 AAO46052 AAP21090 AAQ81319 BAA28218 CAA90306 CAD24593 EDL18008 EDL18009
RNA Seq Atlas 15461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca