Mus musculus Gene: Hras1
Summary
InnateDB Gene IDBG-212024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hras1
Gene Name Harvey rat sarcoma virus oncogene 1
Synonyms c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras-1; Hras1; Kras2; ras;
Species Mus musculus
Ensembl Gene ENSMUSG00000025499
Encoded Proteins
Harvey rat sarcoma virus oncogene 1
Harvey rat sarcoma virus oncogene 1
Harvey rat sarcoma virus oncogene
Harvey rat sarcoma virus oncogene 1
Protein Structure
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] HRAS participates in CpG oligodeoxynucleotide signalling through association with TLR9 and promotion of IRAK1/TRAF6 complex formation in macrophages.
[Homo sapiens] HRAS participates in the activation of MAPK1 by IL1A (IL-1) through association with IRAK1, IRAK2, TRAF6 and MAP3K7.
[Homo sapiens] HRAS promotes virus spread by suppressing viral RNA-induced IFN-beta production through negative regulation of RIG-I signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174775:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141189105-141194005
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000026572 ENSMUSP00000026572
ENSMUST00000097957 ENSMUSP00000095570
ENSMUST00000128993
ENSMUST00000124314
ENSMUST00000124971 ENSMUSP00000138189
ENSMUST00000134008
ENSMUST00000168550 ENSMUSP00000132110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
GO:0032403 protein complex binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0015684 ferrous iron transport
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032855 positive regulation of Rac GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090303 positive regulation of wound healing
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900029 positive regulation of ruffle assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Hemostasis pathway
Signaling by constitutively active EGFR pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
RAF phosphorylates MEK pathway
Signaling by VEGF pathway
EGFR Transactivation by Gastrin pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Cell surface interactions at the vascular wall pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
Immune System pathway
Post NMDA receptor activation events pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
RAF activation pathway
Activation of RAS in B cells pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
EPH-Ephrin signaling pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interleukin receptor SHC signaling pathway
p38MAPK events pathway
EPHB-mediated forward signaling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signaling by FGFR mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Neuronal System pathway
Developmental Biology pathway
SHC-mediated cascade pathway
SOS-mediated signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ARMS-mediated activation pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Tie2 Signaling pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
FCERI mediated MAPK activation pathway
MEK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Endocytosis pathway
Axon guidance pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Hepatitis C pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF8 signaling (Mouse) pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
IL3 pathway
IL5 pathway
IL6 pathway
TSH pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Activation of RAS in B cells pathway
p38MAPK events pathway
EPHB-mediated forward signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Neuronal System pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
RAF activation pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
SHC-related events triggered by IGF1R pathway
Signaling by SCF-KIT pathway
Frs2-mediated activation pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
Post NMDA receptor activation events pathway
IRS-mediated signalling pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
Transmission across Chemical Synapses pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
EGFR Transactivation by Gastrin pathway
Prolonged ERK activation events pathway
EPH-Ephrin signaling pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
RAF phosphorylates MEK pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Endocytosis pathway
Axon guidance pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Hepatitis C pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Signaling pathway from g-protein families [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Il 6 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Integrin signaling pathway [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Regulation of splicing through sam68 [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Mets affect on macrophage differentiation [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Insulin signaling pathway [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Ras signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
Nongenotropic Androgen signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
a6b1 and a6b4 Integrin signaling
IGF1 pathway
EPO signaling pathway
EPHB forward signaling
Endothelins
BCR signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Regulation of Ras family activation
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Fc-epsilon receptor I signaling in mast cells
Insulin Pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt Q61411
TrEMBL B2KGV5 C0H5X4 P97870 Q53WZ3 Q71SW8 Q9QWR5
UniProt Splice Variant
Entrez Gene 15461
UniGene Mm.334313
RefSeq NM_001130443 NM_001130444 NM_008284 XM_006536157 XM_006536160
OMIM
CCDS CCDS22003 CCDS52439
HPRD
IMGT
MGI ID MGI:96224
MGI Symbol Hras
EMBL AC108908 AC157091 AF268311 AJ437023 AY373386 BC011083 BC061885 CH466531 D00836 S39586 S74119 U89950 Z50013
GenPept AAB50559 AAF74295 AAH11083 AAH61885 AAO46052 AAP21090 AAQ81319 BAA28218 CAA90306 CAD24593 EDL18007 EDL18008 EDL18009
ImmGen Hras1 (murine)
RNA Seq Atlas 15461