InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hras1

Summary

InnateDB Protein

IDBP-212030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hras1

Protein Name

Harvey rat sarcoma virus oncogene 1

Synonyms

c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras-1; Hras1; Kras2; ras;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095570

InnateDB Gene

IDBG-212024 (Hras1)

Protein Structure

UniProt Annotation

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Subcellular Localization

Cell membrane {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttles between the plasma membrane and the Golgi apparatus. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0019002	GMP binding
GO:0019003	GDP binding
GO:0030275	LRR domain binding
GO:0032403	protein complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008542	visual learning
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0015031	protein transport
GO:0015684	ferrous iron transport
GO:0019221	cytokine-mediated signaling pathway
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032855	positive regulation of Rac GTPase activity
GO:0034259	negative regulation of Rho GTPase activity
GO:0035022	positive regulation of Rac protein signal transduction
GO:0035176	social behavior
GO:0043406	positive regulation of MAP kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051291	protein heterooligomerization
GO:0051384	response to glucocorticoid
GO:0051385	response to mineralocorticoid
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090303	positive regulation of wound healing
GO:0090398	cellular senescence
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900029	positive regulation of ruffle assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000630	positive regulation of miRNA metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:96224

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF02421
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt