Version 5.4
Homo sapiens Gene: TNRC6A
Summary
InnateDB Gene IDBG-21227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNRC6A
Gene Name trinucleotide repeat containing 6A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090905
Encoded Proteins
IDBP-21229
trinucleotide repeat containing 6A
IDBP-238802
trinucleotide repeat containing 6A
IDBP-373123
trinucleotide repeat containing 6A
IDBP-749607
IDBP-749617
IDBP-751578
IDBP-753551
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:24729695-24827632
Strand Forward strand
Band p12.1
Transcripts
ENST00000315183 ENSP00000326900
ENST00000395799 ENSP00000379144
ENST00000450465 ENSP00000404278
ENST00000491718 ENSP00000460688
ENST00000477487
ENST00000462400
ENST00000464539
ENST00000568903
ENST00000568806
ENST00000563201
ENST00000569376 ENSP00000459297
ENST00000568750 ENSP00000457273
ENST00000569634
ENST00000562829
ENST00000561726
ENST00000567232
ENST00000569098 ENSP00000456394
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010467 gene expression
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005829 cytosol
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052707
View Gene Order
ENSBTAG00000017999
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_118699
Post-transcriptional silencing by small RNAs pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_299
Signaling by NOTCH pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655057 Hs.710391
RefSeq NM_014494 XM_005255254 XM_005255257 XM_006721039
HUGO
OMIM
CCDS CCDS10624
HPRD 11640
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca