InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNRC6A

Summary

InnateDB Protein

IDBP-21229.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNRC6A

Protein Name

trinucleotide repeat containing 6A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326900

InnateDB Gene

IDBG-21227 (TNRC6A)

Protein Structure

UniProt Annotation

Function

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269PubMed:16284622, ECO:0000269PubMed:16284623, ECO:0000269PubMed:17596515, ECO:0000269PubMed:17671087, ECO:0000269PubMed:19056672, ECO:0000269PubMed:19304925}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:11950943, ECO:0000269PubMed:13130130, ECO:0000269PubMed:15494374, ECO:0000269PubMed:15908945, ECO:0000269PubMed:16284622, ECO:0000269PubMed:16284623, ECO:0000269PubMed:16906129, ECO:0000269PubMed:18946079, ECO:0000269PubMed:19056672, ECO:0000269PubMed:19324964}. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11950943}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling