Version 5.4
Mus musculus Gene: Tspan4
Summary
InnateDB Gene IDBG-212299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tspan4
Gene Name tetraspanin 4
Synonyms AI325509; AI746565; D130042I01Rik; NAG-2; Tm4sf7; Tspan-4
Species Mus musculus
Ensembl Gene ENSMUSG00000025511
Encoded Proteins
IDBP-212301
tetraspanin 4
IDBP-400124
tetraspanin 4
IDBP-539005
tetraspanin 4
IDBP-540665
tetraspanin 4
IDBP-532199
tetraspanin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214063:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141475240-141493427
Strand Forward strand
Band F5
Transcripts
ENSMUST00000026585 ENSMUSP00000026585
ENSMUST00000117634 ENSMUSP00000113085
ENSMUST00000138092 ENSMUSP00000115421
ENSMUST00000146305 ENSMUSP00000118533
ENSMUST00000140858 ENSMUSP00000118936
ENSMUST00000130402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000214063
View Gene Order
ENSBTAG00000019369
Not yet available
Cross-References
SwissProt
TrEMBL D3YXS4 D3Z0B7 D3Z0T3
UniProt Splice Variant
Entrez Gene 64540
UniGene Mm.489619 Mm.489933
RefSeq NM_001252588 NM_053082 XM_006536224
OMIM
CCDS CCDS22018
HPRD
IMGT
MGI ID MGI:1928097
MGI Symbol Tspan4
EMBL AC158224
GenPept
RNA Seq Atlas 64540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca