Version 5.4
Homo sapiens Gene: TSPAN4
Summary
InnateDB Gene IDBG-235428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN4
Gene Name tetraspanin 4
Synonyms NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4
Species Homo sapiens
Ensembl Gene ENSG00000214063
Encoded Proteins
IDBP-18518
tetraspanin 4
IDBP-235430
tetraspanin 4
IDBP-235432
tetraspanin 4
IDBP-235434
tetraspanin 4
IDBP-235436
tetraspanin 4
IDBP-235438
tetraspanin 4
IDBP-235440
tetraspanin 4
IDBP-292578
tetraspanin 4
IDBP-292599
tetraspanin 4
IDBP-597476
tetraspanin 4
IDBP-595628
tetraspanin 4
IDBP-588134
tetraspanin 4
IDBP-599391
tetraspanin 4
IDBP-587823
tetraspanin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:842808-867116
Strand Forward strand
Band p15.5
Transcripts
ENST00000346501 ENSP00000324304
ENST00000397411 ENSP00000380558
ENST00000397408 ENSP00000380555
ENST00000397406 ENSP00000380554
ENST00000397404 ENSP00000380553
ENST00000397397 ENSP00000380552
ENST00000397396 ENSP00000380551
ENST00000409531 ENSP00000386899
ENST00000409543 ENSP00000386513
ENST00000464987
ENST00000468468
ENST00000494815
ENST00000530404 ENSP00000437266
ENST00000525334 ENSP00000433980
ENST00000525201 ENSP00000431943
ENST00000526055
ENST00000524895
ENST00000532375 ENSP00000434818
ENST00000527644 ENSP00000436260
ENST00000529566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025511
View Gene Order
ENSBTAG00000019369
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.691297
RefSeq NM_001025234 NM_001025235 NM_001025236 NM_001025237 NM_001025238 NM_001025239 NM_003271 XM_005253102 XM_006718287
HUGO
OMIM
CCDS CCDS41589 CCDS7721
HPRD 04033
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca