InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mmp9

Summary

InnateDB Gene

IDBG-212451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp9

Gene Name

matrix metallopeptidase 9

Synonyms

AW743869; B/MMP9; Clg4b; MMP-9; pro-MMP-9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017737

Encoded Proteins

IDBP-212453

matrix metallopeptidase 9

IDBP-532613

matrix metallopeptidase 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21873432

Mmp9 and Neu1 cross-talk in alliance with Tlr4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce Neu1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells.

PMID 22496659

Mmp9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract.

PMID 22860023

Mmp9 cleaves the pulmonary collectin Sftpd (SP-D) leading to loss of its innate immune functions.

InnateDB Annotation from Orthologs

Summary

PMID 21873432

[Homo sapiens] MMP9 and NEU1 cross-talk in alliance with TLR4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce NEU1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells. (Demonstrated in murine model)

PMID 22496659

[Homo sapiens] MMP9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract. (Demonstrated in mice)

PMID 22860023

[Homo sapiens] MMP9 cleaves the pulmonary collectin SFTPD (SP-D) leading to loss of its innate immune functions. (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100985:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:164940780-164955850

Strand

Forward strand

Band

Transcripts

ENSMUST00000017881	ENSMUSP00000017881
ENSMUST00000137626	ENSMUSP00000120628
ENSMUST00000134382
ENSMUST00000144917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0006508	proteolysis
GO:0007566	embryo implantation
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0051549	positive regulation of keratinocyte migration
GO:1900122	positive regulation of receptor binding
GO:2001258	negative regulation of cation channel activity