Homo sapiens Gene: MMP9 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-78722.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | MMP9 | ||||||||||||||||||||||||||||
Gene Name | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | ||||||||||||||||||||||||||||
Synonyms | CLG4B; GELB; MANDP2; MMP-9 | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000100985 | ||||||||||||||||||||||||||||
Encoded Proteins |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
MMP9 and NEU1 cross-talk in alliance with TLR4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce NEU1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells. (Demonstrated in murine model)
MMP9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract. (Demonstrated in mice)
MMP9 cleaves the pulmonary collectin SFTPD (SP-D) leading to loss of its innate immune functions. (Demonstrated in mouse)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] Mmp9 and Neu1 cross-talk in alliance with Tlr4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce Neu1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells.
[Mus musculus] Mmp9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract.
[Mus musculus] Mmp9 cleaves the pulmonary collectin Sftpd (SP-D) leading to loss of its innate immune functions.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 20:46008908-46016561 | ||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||
Band | q13.12 | ||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Signaling by SCF-KIT pathway
Assembly of collagen fibrils and other multimeric structures pathway
Activation of Matrix Metalloproteinases pathway
Collagen degradation pathway
Developmental Biology pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Axon guidance pathway
Signal Transduction pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Collagen formation pathway
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KEGG |
Leukocyte transendothelial migration pathway
Bladder cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
LPA receptor mediated events
CXCR4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Validated targets of C-MYC transcriptional activation
Regulation of nuclear beta catenin signaling and target gene transcription
AP-1 transcription factor network
FGF signaling pathway
Syndecan-4-mediated signaling events
Plasma membrane estrogen receptor signaling
Syndecan-1-mediated signaling events
amb2 Integrin signaling
Osteopontin-mediated events
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Hs.297413 | ||||||||||||||||||||||||||||
RefSeq | NM_004994 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS13390 | ||||||||||||||||||||||||||||
HPRD | 00387 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||