InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP9

Summary

InnateDB Gene

IDBG-78722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP9

Gene Name

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Synonyms

CLG4B; GELB; MANDP2; MMP-9

Species

Homo sapiens

Ensembl Gene

ENSG00000100985

Encoded Proteins

IDBP-78724

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21873432

MMP9 and NEU1 cross-talk in alliance with TLR4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce NEU1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells. (Demonstrated in murine model)

PMID 22496659

MMP9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract. (Demonstrated in mice)

PMID 22860023

MMP9 cleaves the pulmonary collectin SFTPD (SP-D) leading to loss of its innate immune functions. (Demonstrated in mouse)

InnateDB Annotation from Orthologs

Summary

PMID 21873432

[Mus musculus] Mmp9 and Neu1 cross-talk in alliance with Tlr4 on the cell surface is a novel membrane sialidase-controlling mechanism that depends on ligand binding to its Toll-like receptor (TLR) to induce Neu1 activity, to influence receptor desialylation and subsequently to induce TLR receptor activation and the production of nitric oxide and pro-inflammatory cytokines in dendritic and macrophage cells.

PMID 22496659

[Mus musculus] Mmp9 inhibits influenza virus pathogenesis by mediating neutrophil migration to the respiratory tract.

PMID 22860023

[Mus musculus] Mmp9 cleaves the pulmonary collectin Sftpd (SP-D) leading to loss of its innate immune functions.

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:46008908-46016561

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000372330

ENSP00000361405

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	26 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0006508	proteolysis
GO:0007566	embryo implantation
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030225	macrophage differentiation
GO:0030574	collagen catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0051549	positive regulation of keratinocyte migration
GO:1900122	positive regulation of receptor binding
GO:2001258	negative regulation of cation channel activity

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome