Version 5.4
Mus musculus Gene: Adam11
Summary
InnateDB Gene IDBG-212766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam11
Gene Name a disintegrin and metallopeptidase domain 11
Synonyms AW060611; Mdc
Species Mus musculus
Ensembl Gene ENSMUSG00000020926
Encoded Proteins
IDBP-212768
a disintegrin and metallopeptidase domain 11
IDBP-212770
a disintegrin and metallopeptidase domain 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073670:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102761439-102780262
Strand Forward strand
Band E1
Transcripts
ENSMUST00000103081 ENSMUSP00000099370
ENSMUST00000068150 ENSMUSP00000069466
ENSMUST00000124879
ENSMUST00000141563
ENSMUST00000142912
ENSMUST00000126024
ENSMUST00000134296
ENSMUST00000143269
ENSMUST00000135513
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007229 integrin-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073670
View Gene Order
ENSBTAG00000001735
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.89854
RefSeq NM_001110778 NM_009613
OMIM
CCDS CCDS25503 CCDS48946
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca