Mus musculus Gene: Cars
Summary
InnateDB Gene IDBG-212771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cars
Gene Name cysteinyl-tRNA synthetase
Synonyms CA3
Species Mus musculus
Ensembl Gene ENSMUSG00000010755
Encoded Proteins
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110619:
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143557230-143600090
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000010899 ENSMUSP00000010899
ENSMUST00000105909 ENSMUSP00000101529
ENSMUST00000135032
ENSMUST00000134753
ENSMUST00000146462
ENSMUST00000146904
ENSMUST00000154022
ENSMUST00000134128
ENSMUST00000151574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004817 cysteine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006423 cysteinyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt Q9ER72
TrEMBL Q3U716
UniProt Splice Variant
Entrez Gene 27267
UniGene Mm.125659
RefSeq NM_001252593 NM_013742
OMIM
CCDS CCDS40198 CCDS57597
HPRD
IMGT
MGI ID MGI:1351477
MGI Symbol Cars
EMBL AB015589 AJ276505 AJ276796 AK033328 AK037227 AK077558 AK152866 BC030473 BC054717 BC058954
GenPept AAH30473 AAH54717 AAH58954 BAA29032 BAC28234 BAC29766 BAC36862 BAE31556 CAC16398 CAC16403
RNA Seq Atlas 27267